ĬAR T cells can be either derived from T cells in a patient's own blood ( autologous) or derived from the T cells of another healthy donor ( allogeneic). CAR T cells can be both CD4+ and CD8+, with a 1-to-1 ratio of both cell types providing synergistic antitumor effects. Scientists harvest T cells from people, genetically alter them, then infuse the resulting CAR T cells into patients to attack their tumors. The premise of CAR T immunotherapy is to modify T cells to recognize cancer cells in order to more effectively target and destroy them. The receptors are chimeric because they combine both antigen-binding and T cell activating functions into a single receptor.ĬAR T cell therapy uses T cells engineered with CARs for cancer therapy. Engineered T cells are infused back into the patientĬhimeric antigen receptor T cells (also known as CAR T cells) are T cells that have been genetically engineered to produce an artificial T cell receptor for use in immunotherapy.Ĭhimeric antigen receptors ( CARs, also known as chimeric immunoreceptors, chimeric T cell receptors or artificial T cell receptors) are receptor proteins that have been engineered to give T cells the new ability to target a specific antigens. Engineered T cells are expanded in tissue cultureĥ. Engineered T cells now are now specific a desired target antigenĤ. A new gene encoding a chimeric antigen receptor are incorporated into the T cellsģ. T cells are isolated from a patient's bloodĢ. Chimeric Antigen Receptor T Cell production and infusionġ.
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